Immune-Mediated Diseases and Deficiencies
The immune system plays a key role in numerous conditions. In so-called immune deficiencies, the patient is prone to severe infections due to a lack of naturally occurring protective antibodies (immunoglobulins). Such patients need replacement of the missing immunoglobulins in order to protect them against infections and ensure they can lead a normal life.
Conditions where the immune system is out of balance are generally referred to as immune-mediated diseases, of which auto-immune diseases are a well-known subgroup. Such conditions may lead to various diseases, including bleeding disorders with a reduced number of blood platelets (immune thombocytopenia (ITP)), inflammatory neurologic conditions such as Guillain-Barré syndrome (GBS), and the autoimmune vasculitis Kawasaki disease. Many other organ systems can also be a target of an immune-mediated disease.
Immunotherapy treats many immune diseases and deficiencies by inducing, enhancing, or suppressing an immune response through immunomodulation or immunoglobulin replacement therapy.